Objective: To investigate the effect of Phyllanthus emblica on survival rate and immunoregulation capability in main immune organs and erythrocyte of S180 tumour-burdened mice with serum pharmacology method for evaluation of Chinese herbs. Method: P. emblica fresh fruits were juiced and then stored after freeze-drying. Mice tumor model of S180 burdened was established. Mice were randomly grouped into model group and treatment groups with different doses of P. emblica. Erythrocytes and lymphocytes were separated from blood samples after the last administration of the herb. The mixed rosette test was carried out with tumor erythrocytes and lymphocytes. The effect of different dose of P. emblica was evaluated by inhibition rate of the tumor

spleen index and thymus index. Result: Compared with model group P. emblica of high dose group had significant elevated adherence of lymphocytes to tumor cells promoted by erythrocytes

inhibition for survival rate of tumor cells. The three dosage groups all showed significant regulative effect for immune organs

compared with positive control group. Conclusion: P. emblica inhibits proliferation of tumor and improves immunity function of the hosts.