Objective: To explore the effects of agueous extracts of Cassia obtusifolia on blood pressure

blood lipids

and kidney structure in cold-induced hypertensive mice. Method: C. obtusifolia water extracts was made. Miec were divided into normal control group

cold-stress control group

and cold-stress feeding groups(5

10

20 mg ·kg-1 ·DW)

The control groups were given physiological saline as the control. After 18 days

blood pressure was measured by carotid intubatton and the contents of serum trireactive glyceride(TG)

total cholesterol(CHO)

low density lipoprotein(LDL)

high density lipoprotein(HDL)were also detected. Mice’s kidney were observed by routine histology inspection. Result: The blood pressure of cold-stress control group increased significantly compared with normal control group (P<0.01). Cold-stress feeding groups’ systolic pressure

diastolic pressure and mean arterial pressure were not evident compared with normal control group. The content of TG in cold-stress control group increased than it in normal control group(P<0.01)

and the content of TG

TC in cold-stress feeding groups decreased compared with cold-stress control group(P<0.05). The content of LDL and HDL in cold-stress feeding group(10 mg·kg-1) decreased compared with cold-stress control group(P<0.05)

and the others had no statistical significance compared with cold-stress control group. Renal histologic changes caused by cold-stress show severely enlarged glomeruli

narrowed Bowman’s spaces

and renal tubule edema. Nephrons of the cold-stress feeding groups were similar to the control group. Conclusion: The C. obtusifolia water extracts possesses the effects of decreasing blood pressure and modulating blood lipid contents and improving pathological changes of renal structure.