挤出滚圆法制备泻心汤中黄连效应组分速释微丸的处方工艺研究

谢燕; 胡勇; 马越鸣; 张宁

您当前的位置：

首页 >

文章列表页 >

挤出滚圆法制备泻心汤中黄连效应组分速释微丸的处方工艺研究

更新时间：2024-01-04

- 挤出滚圆法制备泻心汤中黄连效应组分速释微丸的处方工艺研究
- Formulation and Process Optimization of Coptis Effect Components Pellets Prepared by Extrusion-spheronization
- 中国实验方剂学杂志 2010年16卷第16期页码：8-12
- 作者机构：
- 作者简介：
- 基金信息：
  
  上海科委中药现代化资助项目(09dz1971700)
- DOI：
  中图分类号：
- 纸质出版日期：2010
- 稿件说明：
移动端阅览
谢燕, 胡勇, 马越鸣, 等. 挤出滚圆法制备泻心汤中黄连效应组分速释微丸的处方工艺研究[J]. 中国实验方剂学杂志, 2010,16(16):8-12.

XIE Yan, HU Yong, MA Yue-ming, et al. Formulation and Process Optimization of Coptis Effect Components Pellets Prepared by Extrusion-spheronization[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(16): 8-12.
谢燕, 胡勇, 马越鸣, 等. 挤出滚圆法制备泻心汤中黄连效应组分速释微丸的处方工艺研究[J]. 中国实验方剂学杂志, 2010,16(16):8-12. DOI：

XIE Yan, HU Yong, MA Yue-ming, et al. Formulation and Process Optimization of Coptis Effect Components Pellets Prepared by Extrusion-spheronization[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(16): 8-12. DOI：

摘要

目的 :应用挤出滚圆法制备黄连效应组分微丸

研究中药微丸制备的新工艺。方法 :在考察黄连效应组分物理性质的基础上

用新型的挤出滚圆造粒机制备黄连效应组分微丸

采用单因素试验优化制剂处方及工艺条件

评价了微丸的粉体学性质、收率和体外溶出度。结果 :用挤出滚圆法制备的黄连效应组分微丸在15 min内体外溶出均达85%以上

且圆整度好

收率高。结论 :用挤出滚圆法可制备中药微丸

该工艺简便易行

制得的微丸圆整度好

收率高

体外释药迅速。

Abstract

Objective: To prepare Coptis effect components pellets by extrusion-spheronization and study the formulation and new technology process. Method: Based on the physical characters of Coptis effect components

the fast-release pellets of Coptis effect components were prepared by extrusion-spheronization. The formulation and process were studied by direct comparison. Then their characters were evaluated such as powder properties

yield

dissolution etc. Result: The active components could release more than 85% in 15 minutes and the pellets presented perfect sphericity and high yield. Conclusion: Extrusion-spheronization was suitable to produce Chinese herbal medicine pellets. The preparation process was simple and feasible. The spherical degree and yield were high

and active components could release quickly in vitro

关键词

Keywords

references

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

微丸制剂的研究进展及在中药制剂中的应用

离心造粒法制备复方丹参微丸

5-氨基水杨酸结肠定位渗透泵微丸在大鼠体内释药特性考察

4种辅料空白丸芯制备工艺的优选及差异性分析

三七总皂苷脂质体微丸的制备