Objective: To study the therapeutic actions of the Qindaikeyin Pills on animal models of psoriasis. Method: Mice and guinea pigs were randomly divided into blank group

model group

positive group

Qingdaikeyin Pill groups (high

medium

low doses).Each group was orally administered once daily for 14 d.The effects of the pills on epithelial cells mitosis index and number of scale with granular layer in tail epidermis scale in mice were detected by using the pathologic samples of the micevaginal epithelium and scalescuticle at the tails of mice.The model of dermal damage with psoriasis in guinea pigs ears was carried out to observe the pathologic changes in dermal tissue and epidermis thickness. Result: Qindaikeyin Pills showed remarkable inhibitive actions on mitosis of mice vaginal epithelial cell and promotive actions for formation of epidermal granular layer in the scales of the mice tails.Qindaikeyin Pills could decrease the thickness of epidermis with psoriasis in the guinea pigs ears. Conclusion: Qingdaikeyin Pill possesses the significant treatment effect on animal models of psoriasis

which may be attributed to the action of suppressing hyperplasia of epidermal cells and improving imperfect keratinization.