Objective: To study the effect of Huoxue Lishi prescription(HLP) on rats renal injury induced by alcohol. Method : The animal model of alcoholic renal injury was established with the method of direct intragastric infusion of ethanol and HLP. At the end of 4

8

12 weeks

the blood ureanitrogen(BUN)

and creatinine(Scr) were measured and the renal pathological changes were observed by HE staining and transmission electron microscope

respectively. Result : In HLP group

BUN and Cr were all decreased (P<0.05

P<0.01) and some pathological changes

such as hyperplasia of mesangium

interstitial infiltration of inflammatory cell

the degeneration of renal tubularepithelial cell and the dilatation of tubule appeared late and were attenuated as time progressed

compared with that of alcohol group(P<0.05). Conclusion : Huoxue Lishi prescription could inhibit rats renal injury induced by alcohol.