Objective: To observe the clinical effect of Sarcandra glabra. Method: Two hundreds patients with untreated nasopharyngeal carcinoma stage in Ⅲ-IVa were divided into test group and control group randomly.Neoadjuvant chemotherapy and conventional radiotherapy were used in trial.People in test group oral sarcandra 3 days before the radiation therapy

once 10 g

3rd day

until the end of treatment. Result: Two groups of primary and cervical lymph node metastases efficient are 100%

the test group primary and cervical lymph nodes CR is 68%

72%

and the control group is 63%

79%.There is no significant difference between them.Two groups of acute radiation reactions

leukopenia

oral mucositis and skin reaction has no difference.The incidence and severity of xerostomia in test group were lower than control group.Test group 1 year

2 years overall survival

disease-free survival

recurrence rate and distant metastasis rates were:99%

88%

93%

73%

2%

10%

5%

20%;control group was 97%

85%

92%

69%

3%

12%

6%

23%.The difference was not statistically significant.There is no statistically difference between two groups of difficulty in opening mouth and skin fibrosis.There is statistically difference between two groups of xerostomia and the rate of radioactive tooth decay

the test group is lower than the control group. Conclusion: Sarcandra combined with chemoradiation for nasopharyngeal carcinoma can significantly reduce damage from radioactive Parotid

improve acute and long-term xerostomia

reduce the incidence of radioactive decay

it does not affect the treatment of cancer and long-term survival

non-toxic side effects.