Objective: To study the effects of Peitu Yunkang Decoction on abortion model of rat and to investigate the mechanism. Method: The abortion model was established in pregnant rats by giving mifepristone combined with misoprostol.The model was treated with 12

6

3 g ·kg-1 ·d-1 Peitu Yunkang Decoction and 8 mg ·kg-1 ·d-1 progesterone respectively for the model group and normal pregnancy group

normal saline of the same volume was given.All rats were sacrificed on the 14th day after pregnancy.Miscarriage rate

organ coefficient and morphological changes in uterine ovarian tissue were determined. Serum progesterone and β-Human chorionic gonadotropin(β-HCG) were also measured. Result: The group of 12

6

3 g ·kg-1 ·d-1 Peitu Yunkang Decoction increased the content of serum progesterone and β-HCG and the rate of anti-abortion significantly;The 6 g ·kg-1 ·d-1 Peitu Yunkang Decoction group had a better effect than the progesterone group in increasing β-HCG level and reducing the damage in the uterus. Conclusion: Peitu Yunkang Decoction has good effect for the treatment of rat model of threatened abortion

and the dose of 6 g ·kg-1 ·d-1 shows impressive effect.