Objective: To define the present situation of adverse reactions of traditional Chinese medicine (TCM) decoction based on references in recent 30 years. Method: The case reports of adverse reaction caused by TCM decoction were collected from medical literature . Result: The case reports were increased in recent years. Thirty one cases were reported in 25 literatures. In the all cases about 32.25% were severe. The main adverse reaction was allergic reaction. The adverse reaction also happened in digestive system

nervous system and the hematological system. All the patients recovered by withdrawing the decoction and taking symptomatic treatment. Conclusion: TCM decoction can cause adverse reaction

even sometimes cause the severe reaction.Mueti-means and comprehensive analysis can help us to judge the right medicine which bring the adverse reaction and make the judgment more scientifically and accurately.