Glycogen synthase kinase-3β(GSK-3β) can be applied in the regulation of cellular differentiation

proliferation and apoptosis of cancer cells by means of moderating NF-κB signaling pathway and other protein factors. Meanwhile

it plays an important role in the pathogenesis of neuropsychiatric conditions by involvement with the behavioral control of monoamine neurotransmitter. Moreover

GSK-3β mediates the development of neurodegenerative disease by affecting pathways other than Wnt. Consequently

GSK-3β is rapidly becoming a powerful target in the treatment of many critical illnesses. National researchers have made lots of efforts in the research and development of GSK-3β inhibitors

and attained great accomplishments. Therefore

development of various GSK-3β inhibitors to regulate protein factors and signaling pathways is a new strategy for treatment of main diseases.