苦瓜总皂苷对2型糖尿病模型 大鼠胰岛素抵抗、脂联素和瘦素的影响

刘永生; 李晓坤; 王金菊

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苦瓜总皂苷对2型糖尿病模型大鼠胰岛素抵抗、脂联素和瘦素的影响

更新时间：2024-01-04

- 苦瓜总皂苷对2型糖尿病模型大鼠胰岛素抵抗、脂联素和瘦素的影响
- Effects of Total Saponins from Balsam Pear on Insulin Resistance, Adiponectin and Leptin in Rat Model of Type 2 Diabetes
- 中国实验方剂学杂志 2010年16卷第9期页码：177-179
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- 纸质出版日期：2010
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刘永生, 李晓坤, 王金菊. 苦瓜总皂苷对2型糖尿病模型大鼠胰岛素抵抗、脂联素和瘦素的影响[J]. 中国实验方剂学杂志, 2010,16(9):177-179.

LIU Yong-sheng, LI Xiao-kun, WANG Jin-ju. Effects of Total Saponins from Balsam Pear on Insulin Resistance, Adiponectin and Leptin in Rat Model of Type 2 Diabetes[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(9): 177-179.
刘永生, 李晓坤, 王金菊. 苦瓜总皂苷对2型糖尿病模型大鼠胰岛素抵抗、脂联素和瘦素的影响[J]. 中国实验方剂学杂志, 2010,16(9):177-179. DOI：

LIU Yong-sheng, LI Xiao-kun, WANG Jin-ju. Effects of Total Saponins from Balsam Pear on Insulin Resistance, Adiponectin and Leptin in Rat Model of Type 2 Diabetes[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(9): 177-179. DOI：

摘要

目的 : 方法 :探讨苦瓜总皂苷对2型糖尿病模型大鼠血糖、胰岛素抵抗、脂联素和瘦素的影响。方法 :采用高糖高脂加小剂量注射链脲佐菌素(streptozotocin

STZ)造2型糖尿病大鼠模型

通过测定各组血浆血糖、胰岛素、脂联素和瘦素水平

并且计算胰岛素敏感指数

来观察苦瓜总皂苷对2型糖尿病模型的影响。结果 :各用药组可显著降低模型大鼠血浆血糖和胰岛素水平(P<0.01)

显著升高胰岛素敏感指数(P<0.01)

可升高血浆脂联素水平

降低血浆瘦素水平。结论 :苦瓜总皂苷可改善胰岛素抵抗

有降糖的特点。

Abstract

Objective: To explore the effect of total saponins from balsam pear(TSBP) on insulin resistance

adiponectin

leptin in rat model of type 2 diabetes. Method : The mice model of type 2 diabetes was established by eating food containing high sugar and fat and injected a samll dosage of streptozotocin (STZ). The levels of FBG

FINS

adiponectin and leptin in blood plasma were measured

and ISI was calculated. Finally

the effect of TSBP in rat model of type 2 diabetes was evaluated. Result : Compared with control group

TSBP groups and diformin tablet group could significantly decrease the level of FBG and FINS (P<0. 01)

and significantly rise ISI. TSBP groups could elevate the level of adiponectin

and decrease the level of leptin. Conclusion : TSBP can improve insulin resistance and has hypoglycemic action.

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