Objective: Total flavones sustained-release tablets of Dracocephalum were prepared and the influencing factors on release of the tilianin of Dracocephalum were studied . Method: The Dracocephalum total flavones sustained-release tablets were compressed after wet granulating the extracts of Dracocephalum total flavones with HPMC. Then

the influencing factors on release of tilianin were investigated by determining release-rate of tilianin at different time to draw release curve and calculate K value (a kind of index comprehended with cumulative release at 2

6

12 h

respectively) and f2 (similar factorof release curve). Result : The main influencing factors on release-rate of tilianin were the type of HPMC and the ratio of starch to lactose; the amount of HPMC and adhesive were the secondary. Conclusion : The release of tilianin of Saussurea involucrate could be controlled effectively by selecting HPMC K15M as matrices.