ObJective: To study the preventive effects of the combination of ginseng and saffron for acute mountain sickness. Method: Kunming mice were randomized into 5 groups (control

Nuodikang 0.56 g ·kg-1

the combination of ginseng and saffron 20

10

5 g ·kg-1). The combination of ginseng and saffron was administered to mice once daily for 7 days. One hour after the last medication

the survival time was observed in mice using normobaric hypoxia. The time of swimming and the death rate were investigated in mice using hypobaric hypoxia. Result: The combination of ginseng and saffron (20

10

5 g ·kg-1) prolonged the survival time in mice under normobaric hypoxia and the swimming time in mice under hypobaric hypoxia

but had no significant effect on the death rate in mice with hypobaric hypoxia. Conclusion: The combination of ginseng and saffron has anti-hypoxia capacity in mice and can be used to prevent acute mountain sickness induced by environmental hypoxia.