Objective: To review advances of absorption pharmacokinetics study of scutellarin and strategies for its absorption enhancement. Method : According to the findings made in the related researches

absorption characteristic of scutellarin by peroral

nasal

pulmonary and transdermal delivery and the strategies for its absorption enhancement are summarized. Result : The low oral bioavailability could be attributed to its poor solubility both in water and in oil

MRP2-efflux function and metabolism in the gastrointestinal tract. Conclusion : The oral absorption of scutellarin could be enhanced by improving its solubility either in water or in oil

inhibiting drug efflux and developing micro and nano drug delivery systems. In addition

nasal

pulmonary and transdermal drug delivery might be considered as non-invasive systemic delivery of scutellarin.