Objective: To investigate the effect of Jinchai Antivirus Capsules on immunodeficiency mouse with influenza A H1N1 virus (Fort Monmouth/1/47) infection. Method: Mouse model of immunodeficiency was established by injection of cyclophosphamide. Infection of influenza virus FM1 was induced by nose dropping method. Prophylactic administration and therapeutic administration of the capsule were carried out respectively to observe the lung weight and calculate the lung index and virus load. Result: Jinchai Antivirus Capsules markedly decreased the lung index and virus load for the immunodeficiency mouse model with infuluenza virus. The antivirus efficacy was not statistically significant between the Capsules and Tamiflu. Conclusion: Jinchai Antivirus Capsules can distinctly improve the symptom of mouse with pneumonia caused by the infection of influenza virus and have a remarkable effect of prevention and therapy. The efficacy of Jinchai Antivirus Capsules is comparable to that of Tamiflu.