ObJective: Preparation of microcapsules of rutin and its quality evaluation. Method: Gelatin w

as used as capsule material and the rutin microcapsules were prepared by a single pool method.Optimization was performed by orthogonal design.Its preparation

encapsulation efficiency and microcapsule particle size

drug loading

in vitro release were also studied. Result: The optimum condition of rutin microcapsules prepared by this method was as follows:3% gelatin was used with capsule material and heart sac ratio of 1 ∶2;sacculation temperature was at 60 ℃ with stirring speed of 400 r ·min-1.The average encapsulation efficiency of rutin microcapsules obtained by the method was 75.24%.The particle size distribution was 76.40% in 25-35 μm

with an average drug loading of 32.04%.In vitro release of 30.48% reached in 0.5 h and the cumulative release in vitro reached 90% in 12 h. Conclusion: Microcapsules containing drugs prepared by the optimum conditions had shown good reproducibility

process stability

and good sustained action by in vitro release test.