Objective: To investigate effect of Yishen Yifang decoction on insulin resistance and sex hormone in rats with polycystic ovary syndrome (PCOS). Method: The model of PCOS rats induced by testosterone undecanoate and human chorionic gonadotropin (HCG)

afterwards metformin

different doses of Yishen Yifang decoction were taken by intragastric administration for 6 weeks. At the end the contents of fasting blood-glucose (FBG)

2-hours blood glucose after oral glucose tolerance test(OGTT-2hBG)

testosterone (T) insulin-like growth factor-Ι (IGF-1)

estrogen (E2)

progesterone (P)

prolactin (PRL)

insulin(Ins)

tumor necrosis factor (TNF)-α were determined; the changes of insulin sensitivity index (ISI) were counted. Result: Compared with the normal group

the concentrations of FB

OGTT-2hBG

TNF-α

T

IGF-1

E2 and PRL were increased obviously( P <0.01)

but ISI

P were decreased significantly ( P <0.01) in model rats. metformin and Yishen Yifang decoction could improve the pathologic changes in PCOS rats ( P <0.01 or P <0.05); but Yishen Yifang decoction the effects of low-dose group did not change P and ISI ( P >0.05). Conclusion: Metformin and Yishen Yifang decoction can improve the pathologic changes

IR

sex hormone in PCOS rats.