Objective: Compared with cisplatin

study on the inhibitory effect of shuganyishen on Ishikawa cells on mouse model. Method: Immunohistochemical method was used to detect the expressions of ERα

ERβ and PR in the transplantable endometrial carcinoma of mice in control group

shuganyishen group

cisplatin group and shuganyishen-cisplatin group. Result: ERα protein expressed highest in control group

and in cisplatin group

shuganyishen group and shuganyishen-cisplatin group in order. ERβ protein expressed highest in shuganyishen group

and in shuganyishen-cisplatin group

control group and cisplatin group in order. PR protein expressed highest in shuganyishen-cisplatin group

and in shuganyishen group

cisplatin group and control group in order. Conclusion: Shuganyishen has a certain effect on inhibiting endometrial carcinoma. Furthermore

shuganyishen combined with conventional chemotherapy is good to inhibit tumor and ERα and improve the expression of PR

without affecting ERβ. So the combined prescription can solve the problem of estrogen inhibition caused by using chemotherapy alone.