Objective: To investigate therapeutic effects of total saponins extracted from leaves of rehmannia on accelerated nephrotoxic nephritis induced by rabbit IgG in rat. Method: Rephrotoxic serum containing antibody to rat basilar membrane was preparcd in rabbits.For establishing accelerated nephrotoxic mephritis in rat

the seruem was obtained and given to rat by injection through tail venule.Total saponins extracted from leaves of rehmannia were orally given to the model rats as treatment for 16 days at doses of 20~40 mg·kg-1.Blood biochemeical parameters

urine protein

hemorheological parameters and pathological changes of nephritis were employed to evaluate the efficacy the efficacy of the treatment. Results :Compared with the model rats

plasma albumin

cholesterol and urea nitrogen were significantly increased. There was also a tendency of normalization for hemorheological parameters.The pathological changes of nephritis were alleviated. Conclusion :Total saponins extracted from leaves of rehamannia has therapeutic effect with a dose-response manner on accelerated nephrotoxic nephritis induced by rabbit IgG in rat.