XUE Xiao-ping, LI Dong-hua, ZHANG Hao, et al. Experimental Study on the Effect of Qingre Jiedu Fang on the Levels of Endotoxin and Cytokines in Rats with Acute Intra-abdominal Infection[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 176-178.
XUE Xiao-ping, LI Dong-hua, ZHANG Hao, et al. Experimental Study on the Effect of Qingre Jiedu Fang on the Levels of Endotoxin and Cytokines in Rats with Acute Intra-abdominal Infection[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 176-178.DOI:
Objective: To explore the effects of Qingre Jiedu Fang (QRJD Fang) on the secretion of endotoxin
TNF-α
IL-6 and IL-10 in intra-abdominal infection rats. Method: After giving 30 min of i.g QRJD Fang or cefi xime(ANT)
rat model of acute bacterial peritonitis was set up. Endotoxin
tumor necrosis factor-α(TNF-α)
interleukin-6 (IL-6) and interleukin-10(IL-10) in serum were determined respectively in 6h
12h
18h
24h after acute bacterial peritonitis in the four groups(control group
model
QRJD Fang group
ANT group). Result: Compared with the control group
serum endotoxin
TNF-α
IL-6 and IL-10 in the model were increased obviously (P<0.01)
while the indexes in QRJD Fang group and ANT group were decreased (P<0.01 or P<0.05). Conclusion: QRJD Fang could obviously inhibit the secretion of inflammatory cytokints
such as endotoxin
TNF-α
IL-6 and IL-10 in the acute intra-abdominal infection rats.