Objective: To outline the application of biotechnology in decreasing the toxicity and increasing the efficacy of Tripterygium. Method : The related literatures

including articles concerning biologically targeting drug delivery

modifying a ingredient by enzymes or cells

isolating effective components from endophytes and the overall fermentation of Tripterygium. Result : By delivering drugs to the lesion site

modifying an ingredient

isolating effective components from endophytes and overall fermenting of Tripterygium

the biotechnology could decrease the toxicity and increase the efficacy of Tripterygium at both monomer and overall level. Conclusion : The application of biotechnology

including biotransforming effective ingredients of Tripterygium by type and genetic engineering bacteria

screening the best targets from the related genes of biotical detoxification and toxicological effects

and synthesizing their inhibitors to get the efficacy components

will be an important direction in the research of Tripterygium.