MEI Ying, FENG Wei-hong, LIU Shu-zhi, et al. Effects of Different Prescription of Microemulsion on Transdermal Permeability on Drugs[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(10): 1-4.
MEI Ying, FENG Wei-hong, LIU Shu-zhi, et al. Effects of Different Prescription of Microemulsion on Transdermal Permeability on Drugs[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(10): 1-4.DOI:
Objective: Investigated the effects of different prescription of microemulsion on transdermal permeability on Zuojin microemulsion based gel. Method: Improved Franz diffusion cell was adopted to research the transdermal permeability difference between these kinds of gels in mouse skin in vitro
and HPLC was used to determine the content of hydrochloride palmatine
berberine
evodiamine and rutaecarpine in receiving solution. Result :The permeation rate and 24 h accumulation transmittance of hydrochloride palmatine
berberine
evodiamine and rutaecarpine in different Zuojin microemulsion based gel were distinct. Conclusion: The transdermal permeability of drugs is influenced by the composition of microemulsion prescription.