Objective: To study the inhibitory effect of Boschniakia rossica extracts (BRE) on lipid peroxidation of plasma lipoproteins in rabbits with hyperlipidemia. Method: The hyperlipidemic model were established by feeding rabbits with high-fat diet. After 8 weeks of treatment

plasma lipoproteins were isolated

and then lipid peroxide (LPO) and susceptibility of low density lipoprotein (LDL) to oxidation was investigated. Result: After the administration with BRE

the levels of plasma total cholesterol (TC)

very low density lipoprotein cholesterol (VLDL-CH) and low density lipoprotein cholesterol (LDL-CH) in hyperlipidemic rabbits were significantly reduced; LPO levels of plasma and lipoproteins were significantly decreased; and the lag phage of LDL oxidation curve in vitro was noticeably prolonged. Conclusion: BRE

which can reduce blood lipids

decrease the lipid peroxidizability of lipoproteins and promote resistance to LDL oxidation

may be useful in the prevention and treatment of atherosclerosis.