Objective: To study the effect of Puwei Pill(PWP) on the anti-oxidation and improvement of the gastric mucosal blood flow in the rats with gastric ulcer recurrence. Method: The gastric ulcer recurrence model was developed by intraperitoneal injection with interleukin-1β(IL-1β). Then the pathohistological structure in the recurred gastric ulcer

treated by PWP(ig

90 d)

was observed. The superoxide dismutase(SOD)

nitric oxide(NO)

malondialdehyde(MDA) and endothelin-1 (ET-1) in the plasma and ET-1A expressed in the gastric mucosa were determined. Result: PWP could significantly resist the recurrence of gastric ulcer

increase the SOD

NO activity and decrease the contents of MDA and ET-1 in plasma. At the same time

PWP could significantly inhibit the ET-1A expression in the gastric mucosa. Conclusion: PWP can prevent the recurrence of the gastric ulcer

which mechanism is probably related to the increase of anti-oxidation capacity and improvement of mucosal blood flow.