Objective: To study the effect on antipyretic and anti-inflammatory of Qingkailing Ingection(QKL) processed by ultrofiltration(UF). Method: By using antipyretic and anti-inflammatory as the major pharmacodynamic indicators

to investigate the effect of QKL on inhibition of rabbit increasing temperature induced by LPS

of rat hind paw edema induced by carrageenan and of rat cotton ball granuloma. Result: Both the group of QKL processed by UF and the group of original procedure have obvious effect on antipyretic after 1 hour. Compared with model group

P<0.01

P<0.05; They have obvious effect on anti-inflammatory after 2 hour. Compared with model group

P<0.05

There is no significant difference between the two groups; 14 mL ·kg-1 dose group of QKL processed by UF and group of original procedure have inhibition of proliferative inflammation. Compared with model group

P<0.01

P<0.05

There is significant difference on dry weight of cotton balls between the two groups

P<0.01. Conclusion: Compared with QKL processed by original procedure

QKL processed by UF has similar action of antipyretic and anti-inflammatory

to some extent

stronger effects.