Objective: To establish a method for the determination of corilagin and gallic acid in Yiganjiedu oral liquid. Method: A HPLC method was developed. A Diamonsil C18 column (4.6 mm×150 mm

5μm) was used

with the mobile phase of acetonitrile-0.1% phosphonic acid (12 ∶88)

and flow rate of 1.0 mL·min-1. The column temperature was at 30℃ and the detection wavelength was at 274 nm. Result: The linear range of corilagin was 0.274-1.918 μg(r=0.999 9)

the mean recovery was 96.55% (n=6); that of gallic acid was 0.196-1.372 μg(r=0.999 9)

the mean recovery was 97.91%(n=6). Conclusion: This method is quick

simple

accurate and specific

and can be used for determination of corilagin and gallic acid in Yiganjiedu oral liquid.