Objective: To study the pharmacokinetics of curcumin microcystin in rats. Methods: The microcystin was orally administrated. After carotid artery cannulation

blood samples were collected after administration of 0.08

0.25

0.5

0.75

1

2

3

4

5.5 h

and tested by HPLC. Results: The various doses of curcumin concentration-time curve is bimodal; Cmax1 and Cmax2 of each dose group are as follows: high-dose(0.90

1.20 mg/L)

medium dose(0.43

0.46 mg/L)

low dose(3.16

1.31 mg/L); AUC are 3.79

2.60

5.92 mg·h/L respectively. Cmax and AUC of low dose are greater than that of the high and medium doses. Conclusion: The Pharmacokinetics of curcumin were nonlinear process in rat

there may be the phenomenon of enterohepatic circulation.