Objective: To study the influence of the formula of benefiting Qi and promoting blood circulation and detoxication on juvenile spontaneously hypertensive rats(SHR)’ endothelium function

and further investigate the prevention mechanism of HBP by the formula. Method: 16 6ws-old male SHR rats were randomly divided into two groups

including the model group and the formula group. After 6 weeks

the changes in blood pressure before and after treatment were detected separately. Besides

the change of serum von Wilebrand factore(vWF) and ET-1 concentration were tested by enzyme linked immunosorbent assay

the content of serum NO was tested by nitrous reductase chromatometry

the SOD was tested by xathine and xanthylic oxidase reaction system

and the MDA was tested by thiobarbital chromatometry. Meanwhile 8 same age WKY rats were used as the blank comparison. Results : In the juvenile plasma

vWF and MDA were significantly (P<0.05) increased

NO and SOD were significantly (P<0.05) decreased. After treatment with the formula of benefiting Qi and promoting blood circulation and detoxication

not only vWF and MDA were significantly (P<0.05) decreased

but also NO and SOD were significantly (P<0.05) increased in the SHP plasma. Conclusion : The insufficiency of endothelium in SHR exists in juvenile stage. The early application with the formula of benefiting Qi and promoting blood circulation and detoxication can improve vascular endothelial function in juvenile SHR.