Objective:To investigate the effect mechanism of Zhinao Capsule in treating Alzheimer disease and effect on brain-derived neurotrophic factors (BDNF) and tyrosine protein kinase receptors in the tissue of experimental rat model of Alzheimers disease. Methods:Male Wistar rats were divided randomly into 7 groups: (1)normal group; (2)Sodium Chloride group; (3)model group;(4) huperzine A group; (5)low dose group of Zhinao Capsule; (6)middle dose group of Zhinao Capsule; (7) high dose group of Zhinao Capsule. According to "Brain stereotaxic atlas of rats "

animal models of Alzheimer dementia were established by injecting IBO into Meynert basal nuclear. The content of BDNF and TrkB receptor in brain tissue (cortex and hippocampus) were detected by means of ELISA. Results:Compared with model group

Zhinao Capsule could significantly enhance the content of BDNF as well as its TrkB receptor in the cortex and hippocampus of the rats (P<0.05). The performance of high

middle dose of Zhinao Capsule

and huperzine A treated group in improving the content of BDNF and TrkB in brain tissue was higher than low dose group of Zhinao Capsule(P<0.05). The performance of high

middle dose group of Zhinao Capsule was not higher than that in huperzine A group(P(0.05). Conclusions: Zhinao Capsule has the function of improving the learing-memory ability in model rats

its function mechanism mainly is that Meynert basal neuclea synthesize acetylcholine

transporting more acetylcholine to cortex and hippocampus. Zhinao Capsule can improve the neurons who synthesize BDNF content and express more TrkB receptors.