Objective: To observe the The therapeutical effect and toxicologic study of Lixin granule on the adriamycin-induced heart failure rats. Method: sixty adult male Wistar rats were divided into 5 groups: normal control group

adriamycin(ADR) group

L- Lixin granule group

H- Lixin granule group

captopril group. Then ADR of 5 mg·kg-1 was given intraperitoneally once to copy the model of heart failure once 5 days

totally 3 frequency. Objective to monitor the hemodynamic index on the adriamycin-induced heart failure rats through left ventricle intubatton.Pathological changes were observed by HE staining.The LD50 and maximum tolerance of heart failure rats were determined on toxicologic study.Another three-dose group )-1] and blank control group were oral administrated.8 weeks later

the body weight were measured.The conditions of blood

the liver and renal functions were determined after treatment as well as following seven days. The rats were sacrificed after the experiment.Meanwhile

the coefficient of organ was calculated and the pathology was also tested. Result: As compared with ADR group

the LVSP the Lixin granule group were significantly higher and HE staining showed that the myocardial tissue damage were significantly improved. By tests of mouse toxicity

sixtyfold-weight Lixin granule than sdult is revealed that the rats was orally administered through a stomach and Lixin granule is an actually nonpoisonous material. After a long period of time

the weight

routine blood test

liver

kidney function and main viscera of rats were not influenced obviously. Conclusion: Lixin granule treatment can improve the cardiac contractility of adriamycin-induced heart failure rats; and also obviously be provided with better security.