Objective: To observe the effects of aqueous extract of alcohol of the roots of Apium graveolens on blood pressure and underlying the mechanisms in renal hypertension rats. Method: Two-kidney one clip (2K1C) renal hypertension rats were randomly divided into negative control group

model group

the positive control (Captopril

CAP) group and the roots of A. graveolens extract high

medium low-dose group and

the daily perfusion for 16 week at any time adjust the dose according to weight capacity

periodic determination of rat tail artery systolic and diastolic blood pressure.After the last administration

after separation of the abdominal aorta blood

take heart

left ventricular weight (LVW) / body weight (BW) ratio

superoxide dismutase (SOD) activity

malondialdehyde (MDA)

vascular tone factor Ⅱ (Ang Ⅱ)

endothelin (ET) content. Result: The roots of A. graveolens extract L treatment group was significantly higher SOD activity

lower MDA content and significantly decreased plasma ET levels. The roots of A. graveolens plasma high-dose group were significantly lower Ang Ⅱ levels. Conclusion: The roots of A. graveolens extract can depress blood pressure in rats with renal hypertension.