Objective: To observe anti-hepatic fibrosis(HF) effect of Guangxi Curcuma kwangsiensis (GGYJ). Method: The models of rat with HF were duplicated by hypodermic injection CCl4.Colchicine(Col) were used as a positive control.The quantities of hydroxyproline(Hyp)

Malondialdehyde(MDA)

superoxide dismutase(SOD) and Glutathione peroxidase(GSH-Px) in liver tissue were determined.The pathological shapes of liver tissue and the level of HF by using HE and Masson staining were observed. Results: GGYJ could reduce remarkably the quantities of Hyp and MDA

and rise the quantities of SOD and GSH-Px.Compared with model group

there are obvious differences in high dose and mid-dose groups of GGYJ(P＜0.01) .And there are differences in low dose groups of GGYJ(P＜0.05) .Meanwhile

high dose and mid-dose groups of GGYJ could reduce remarkably the level of fibrosis in liver tissue(P＜0.01

P＜0.05)

while low dose groups of GGYJ did’nt have this action. Conclusions: GGYJ has anti-HF action. The actions of high dose group of GGYJ are better.Its mechanisms may relate to clearing out free radical

anti-lipoid peroxidation and anti-liver injury.