参附汤、芪附汤、姜附汤对阿霉素心脏毒性损伤 大鼠线粒体途径细胞凋亡的影响

范颖; 才丽平; 于彩娜; 徐丹; 林庶茹

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参附汤、芪附汤、姜附汤对阿霉素心脏毒性损伤大鼠线粒体途径细胞凋亡的影响

更新时间：2024-01-04

- 参附汤、芪附汤、姜附汤对阿霉素心脏毒性损伤大鼠线粒体途径细胞凋亡的影响
- Effects of Shenfu Decoction, Qifu Decoction, Jiangfu Decoction on Cardiomyocyte Apoptosis Through Mitochondrion Signaling Pathway of Cardial Injury Model Induced by Adriamycin in Rat
- 中国实验方剂学杂志 2010年16卷第8期页码：135-138
- 作者机构：
- 作者简介：
- 基金信息：
  
  辽宁省教育厅创新团队项目(2007T117)
- DOI：
  中图分类号：
- 纸质出版日期：2010
- 稿件说明：
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范颖, 才丽平, 于彩娜, 等. 参附汤、芪附汤、姜附汤对阿霉素心脏毒性损伤大鼠线粒体途径细胞凋亡的影响[J]. 中国实验方剂学杂志, 2010,16(8):135-138.

FAN Ying, CAI Li-ping, YU Cai-na, et al. Effects of Shenfu Decoction, Qifu Decoction, Jiangfu Decoction on Cardiomyocyte Apoptosis Through Mitochondrion Signaling Pathway of Cardial Injury Model Induced by Adriamycin in Rat[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(8): 135-138.
范颖, 才丽平, 于彩娜, 等. 参附汤、芪附汤、姜附汤对阿霉素心脏毒性损伤大鼠线粒体途径细胞凋亡的影响[J]. 中国实验方剂学杂志, 2010,16(8):135-138. DOI：

FAN Ying, CAI Li-ping, YU Cai-na, et al. Effects of Shenfu Decoction, Qifu Decoction, Jiangfu Decoction on Cardiomyocyte Apoptosis Through Mitochondrion Signaling Pathway of Cardial Injury Model Induced by Adriamycin in Rat[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(8): 135-138. DOI：

摘要

目的 :探讨参附汤、芪附汤、姜附汤对阿霉素心脏毒性损伤大鼠线粒体途径细胞凋亡的影响。方法 :采用酶联免疫测定法(ELISA)测定心肌线粒体抗凋亡基因(Bcl-2)

促凋亡基因(Bax)

细胞色素c(cytc)

半胱氨酸天冬氨酸蛋白酶9(Caspase-9)

半胱氨酸天冬氨酸蛋白酶3(Caspase-3)含量。结果 :阿霉素组心肌线粒体Bcl-2含量降低、Bax含量提高

cytc

Caspase-9

Caspase-3含量上升

均有统计学意义(P＜0.05)。参附汤、芪附汤、姜附汤3组心肌线粒体Bcl-2含量提升、Bax含量下降

cytc

Caspase-9

Caspase-3含量下降

均有统计学意义(P＜0.05)。结论 :Bcl-2

Bax

cytc

Caspase-9

Caspase-3与阿霉素心脏毒性损伤发生、发展过程有关

参附汤、芪附汤、姜附汤通过抑制线粒体途径的细胞凋亡保护心肌抑制阿霉素心脏毒性损伤。

Abstract

Objective: To investigate the effect of Shenfu Decoction

Qifu Decoction

Jiangfu Decoction on cardiomyocyte apoptosis through the mitochondrion signaling pathway of cardial injury model induced by adriamycin in rat. Methods : Enzyme-linked immunosorbent assay(ELISA) was applied to measure the content of Caspase-9

Caspase-3

Bcl-2

Bax and cytochrome C in cardiomyocyte mitochondria. Results : In adryamycin-induced rat group: the content of Bcl-2 in myocardial mitochondria decreased

the content of Bax increased

the content of Caspase-9

Caspase-3 and cytochrome C increased

with statistical significance (P<0.05). In Shenfu Decoction group

Qifu Decoction group and Jiangfu Decoction group: the content of Bcl-2 in myocardial mitochondria increased

the content of Bax decreased

the content of Caspase-9

Caspase-3 and cytochrome C decreased

with statistical significance (P<0.05). Conclusion : There is relationship between the content of Caspase-9

Caspase-3

Bcl-2

Bax and cytochrome C and the ocurrence and development of adriamycin-induced cardial injury. Shenfu Decoction

Qifu Decoction

Jiangfu Decoction can protect myocardium by inhibiting adriamycin-induced cardiomyocyte apoptosis through the mitochondria signaling pathway.

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