山芝麻对CCl诱导小鼠肝损伤的 脂质过氧化反应的影响

林兴; 黄权芳; 张士军; 廖明; 黄仁彬

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山芝麻对CCl诱导小鼠肝损伤的脂质过氧化反应的影响

更新时间：2024-01-04

- 山芝麻对CCl诱导小鼠肝损伤的脂质过氧化反应的影响
- Influence of Water Extract from on Lipid Peroxidation Induced by Carbon Tetrachlorile in Mice
- 中国实验方剂学杂志 2010年16卷第10期页码：147-149
- 作者机构：
- 作者简介：
- 基金信息：
  
  广西教育厅自然科学基金面上项目(200911MS28)
- DOI：
  中图分类号：
- 纸质出版日期：2010
- 稿件说明：
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林兴, 黄权芳, 张士军, 等. 山芝麻对CCl诱导小鼠肝损伤的脂质过氧化反应的影响[J]. 中国实验方剂学杂志, 2010,16(10):147-149.

LIN Xing, HUANG Quan-fang, ZHANG Shi-junv, et al. Influence of Water Extract from on Lipid Peroxidation Induced by Carbon Tetrachlorile in Mice[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(10): 147-149.
林兴, 黄权芳, 张士军, 等. 山芝麻对CCl诱导小鼠肝损伤的脂质过氧化反应的影响[J]. 中国实验方剂学杂志, 2010,16(10):147-149. DOI：

LIN Xing, HUANG Quan-fang, ZHANG Shi-junv, et al. Influence of Water Extract from on Lipid Peroxidation Induced by Carbon Tetrachlorile in Mice[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(10): 147-149. DOI：

摘要

目的 :研究山芝麻水提物(Helicteres angustifolia)对四氯化碳(CCl4)诱导肝损伤小鼠脂质过氧反应的影响。方法 :以CCl4造成小鼠急性肝损伤模型

山芝麻ig

测定血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)活性、丙二醛(MDA)含量、超氧化物歧化酶(SOD)活性、总抗氧化能力(T-AOC)

以及检测肝组织MDA

SOD

NO和T-AOC含量。结果 :山芝麻能保护CCl4所致小鼠肝损伤

使血清ALT

AST活力和MDA含量下降

SOD活性和T-AOC水平提高。山芝麻还能提高肝组织SOD

T-AOC含量

降低MDA

NO水平。结论 :山芝麻具有抗脂质过氧化作用。

Abstract

Objective: To study anti-lipid peroxidation effects of the water extract from H. angustifolia(HA) on liver damage induced by carbon tetrachlorile (CCl4) in mice. Method: After acute liver injury model was induced by CCl4

mice were administrated intragastrically with water extract of H. angustifolia

the content of alanine transaminase (ALT)

aspartate aminotransferase (AST)

malondialdehyde (MDA) and activity of superoxide dismutase (SOD)

ability of total antioxidation capacity (T-AOC) were measured respectively in serum. The levels of MDA

SOD

T-AOC were evaluated respectively in liver. Result: H. angustifolia could markedly decrease ALT

AST

MDA content

increase SOD activity and ability of T-AOC respectively in serum

also could increase the content of SOD and T-AOC

decrease the levels of MDA and NO respectively in liver. Conclusion: H. angustifolia has the effect of anti-lipid peroxidation.

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