Objective:To observe the effects of Chai Shao He Wei Granules (CSHW) on chronic superficial gastritis in mouse model induced by methimazole．Methods:Established mice model of chronic superficial gastritis by administrating methimazole for 28 days；Three weeks after drug administration histopathology of gastric mucosa was observed by HE stain．The contents of PGE2，phosphatide and aminohexose in gastric mucosa were detected by chemical colorimetry；and the content of serum gastrin was detected by radioimmunoassay．Results:Compared with model group，CSHW high dose group could reduce the pathological damage of chronic superficial gastritis in mice，increase the content of aminohexose，elevate the levels of PGE2 and phosphatide and reduce the level of gastrin in serum，respectively．Conclusions:CSHW could obviously reduce the inflammation and damage in gastric mucosa of chronic superficial gastritis induced by methimazole in mice and protect the gastric mucosa．The effect may be related to the increase of aminohexose in gastric mucosa，raise of phosphatide and PGE2，reduction of serum gastrin．