健脾补肾方对家兔激素性股骨头坏死模型脂质代谢的影响

李玉彬; 谢利民; 李 理; 徐颖鹏; 于 潼; 刘家伟; 王志勇

您当前的位置：

首页 >

文章列表页 >

健脾补肾方对家兔激素性股骨头坏死模型脂质代谢的影响

更新时间：2024-09-23

- 健脾补肾方对家兔激素性股骨头坏死模型脂质代谢的影响
- The Effect and Mechanism of Radix Notoginseng Compound on Inhibition of Thrombosis
- 中国实验方剂学杂志 2010年16卷第2期页码：90-93
- 作者机构：
- 作者简介：
- 基金信息：
  
  辽宁省自然科学基金项目(20062055)
- DOI：
  中图分类号：
- 纸质出版日期：2010
- 稿件说明：
移动端阅览
李玉彬, 谢利民, 李理, 等. 健脾补肾方对家兔激素性股骨头坏死模型脂质代谢的影响[J]. 中国实验方剂学杂志, 2010,16(2):90-93.

The Effect and Mechanism of Radix Notoginseng Compound on Inhibition of Thrombosis[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(2): 90-93.
李玉彬, 谢利民, 李理, 等. 健脾补肾方对家兔激素性股骨头坏死模型脂质代谢的影响[J]. 中国实验方剂学杂志, 2010,16(2):90-93. DOI：

The Effect and Mechanism of Radix Notoginseng Compound on Inhibition of Thrombosis[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(2): 90-93. DOI：

摘要

目的: 探讨健脾补肾方防治疗激素性股骨头坏死的作用机制。方法: 采用激素性股骨头坏死(SINFH)模型

以蒸馏水作为空白对照

观察各实验组治疗后的病理形态学变化

并对各实验组血脂指标进行动态监测。结果: 健脾补肾方能明显改善家兔SINFH模型组织形态学

12周时股骨头标本HE染色证明各治疗组空骨陷窝率和髓腔脂肪面积与模型组比较差异显著或非常显著(P<0.05或P<0.01);健脾补肾方可纠正激素造成的脂质代谢紊乱状况

各治疗组与模型组比较

在治疗后的4周和(或)8周和(或)12周

各项血脂指标差异显著或非常显著(P<0.05或P<0.01)。结论: 健脾补肾方对SINFH的防治机理可能与纠正激素造成的脂质代谢紊乱有关。

Abstract

Objective: To study the effect and mechanism of Radix Notoginseng compound on inhibition of thrombosis. Methods: The rat thrombosis nodel was induced by electric stimulation. The influences of Radix Notoginseng Compound on thrombus formation and hemorheological parameters were investigated. The rat model of blood stasis was established by combined application of epinephrine with ice bath. The influences of the compound on thrombixin A2 and prostaglandin I2 were observed for the model. Results: Compared with the control group

each dose of Radix Notoginseng Compound and aspirin tablet could extend the latency period for thrombus formation

and decrease blood viscosity. The compound could significantly increase the plasma levels of 6-Keto-PGF1α and the ratio of 6-Keto-PGF1α/TXB2 for the blood stasis rats (both P<0.01). The level of TXB2 was significantly decreased (P<0.05). Conclusion: Radix Notoginseng compound has inhibitive effect on thrombosis

the mechanism of action is closely related with decrease in blood viscosity and chang in the PGI2/TXA2 ratios.

关键词

Keywords

references

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

暂无数据