正交试验法优选皮肤辐射防护膏药材 中醇溶性成分的提取工艺

杨安平; 陈耀宗; 陈少宏; 李韵珊

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正交试验法优选皮肤辐射防护膏药材中醇溶性成分的提取工艺

更新时间：2024-01-04

- 正交试验法优选皮肤辐射防护膏药材中醇溶性成分的提取工艺
- Study on Extraction Process for Total Mollugin in Cream with Protecting Skin Against Radiation by Orthogonal Design
- 中国实验方剂学杂志 2010年16卷第9期页码：19-21
- 作者机构：
- 作者简介：
- 基金信息：
  
  佛山市科技发展专项资金项目(03080161)
- DOI：
  中图分类号：
- 纸质出版日期：2010
- 稿件说明：
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杨安平, 陈耀宗, 陈少宏, 等. 正交试验法优选皮肤辐射防护膏药材中醇溶性成分的提取工艺[J]. 中国实验方剂学杂志, 2010,16(9):19-21.

YANG An-ping, CHEN Yao-zeng, CHEN Shao-hong, et al. Study on Extraction Process for Total Mollugin in Cream with Protecting Skin Against Radiation by Orthogonal Design[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(9): 19-21.
杨安平, 陈耀宗, 陈少宏, 等. 正交试验法优选皮肤辐射防护膏药材中醇溶性成分的提取工艺[J]. 中国实验方剂学杂志, 2010,16(9):19-21. DOI：

YANG An-ping, CHEN Yao-zeng, CHEN Shao-hong, et al. Study on Extraction Process for Total Mollugin in Cream with Protecting Skin Against Radiation by Orthogonal Design[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(9): 19-21. DOI：

摘要

目的 :优选皮肤辐射防护膏药材中醇溶性成分的提取工艺。方法 :设计L9(34)正交试验

采用HPLC测定大叶茜草素的含量作为质控指标

考察乙醇用量(A)、乙醇浓度(B)、提取时间(C)、和提取次数(D)4个因素对皮肤辐射防护膏药材中醇溶性成分提取的影响

优化提取工艺。结果 :最佳提取条件为:加入12倍药材量95%乙醇

提取3次

每次1.5 h。结论 :该提取工艺稳定性和重现性良好

简便

快速

可行。

Abstract

Objective: To study the optimum extraction process of alcohol-soluble components in cream with protecting skin against radiation. Method: By use of orthogonal experimental design L9(34)

four factors that may effect the extraction had been studied

including volume and concentration of alcohol

extracting time and times.And the content of mollugin was determined by HPLC to screen out the best method of extraction conditions. Result :The best extracting technical conditions were as follows:12 times of 95% EtOH

extracting with reflux for 1.5 hours and 3 times. Conclusion :The optimized process was simple

fast and feasible with its stability and repeatability.

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