Objective: To observe the protective effects of Baoligan capsule on acute alcohol induced liver injury in mice. Methods: After oral administration of Baoligan (300 and 600 mg·kg-1) for seven days

the mice were administrated alcohol(8 g·kg-1)to induce liver injury. Hepatic function was evaluated by assessing alanine aminotransferase (ALT) level in plasma. TBARS method was performed to detect the contents of malondialdehyde (MDA) in liver. Antioxidant capacity of liver was measured by oxygen radical absorbance capacity (ORAC) assay. The contents of glutathione (GSH) were detected in liver by HPLC method. Hepatic glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were detected by enzymology method. Results: Baoligan capsule decreased the levels of ALT in plasma and the content of MDA in liver. It also increased the levels of ORAC

GSH

GSH-Px and SOD in liver as compared with alcoholic control group. Conclusion : Baoligan capsule exerted protective effects on liver injury in mice loaded with alcohol.