Objective: To study the effect and mechanism of Radix Notoginseng compound on inhibition of thrombosis. Methods: The rat thrombosis nodel was induced by electric stimulation. The influences of Radix Notoginseng Compound on thrombus formation and hemorheological parameters were investigated. The rat model of blood stasis was established by combined application of epinephrine with ice bath. The influences of the compound on thrombixin A2 and prostaglandin I2 were observed for the model. Results: Compared with the control group

each dose of Radix Notoginseng Compound and aspirin tablet could extend the latency period for thrombus formation

and decrease blood viscosity. The compound could significantly increase the plasma levels of 6-Keto-PGF1α and the ratio of 6-Keto-PGF1α/TXB2 for the blood stasis rats (both P<0.01). The level of TXB2 was significantly decreased (P<0.05). Conclusion: Radix Notoginseng compound has inhibitive effect on thrombosis

the mechanism of action is closely related with decrease in blood viscosity and chang in the PGI2/TXA2 ratios.