LI Hua, YE Ting-jie, LI Bo-qing, et al. Cordyceps polysaccharides reduce cell oxidative damage in cultured fiboblasts[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(4): 160-162.
LI Hua, YE Ting-jie, LI Bo-qing, et al. Cordyceps polysaccharides reduce cell oxidative damage in cultured fiboblasts[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(4): 160-162.DOI:
Objective: To observe effects of cordyceps polysaccharides(CP)on reducing cell oxidative damage in cultured fibroblasts. Methods: Oxidative models were induced by 8-MOP/UVA. Cordyceps polysaccharides was administrated before 8-MOP/UVA. MDA
SOD
CAT
GSH-Px enzyme activities were measured for examination of free radicle amount and clearance ability of the cell. Mitochondrial transmembrane potential were tested to examine mitochondria function. Results: In the model group
free radicals increased compared with that in the control group and enzyme activities of free radical scavenging decreased. Severity of mitochondrial transmembrane potential damage were also relieved
which were reversed in CP protected groups. Conclusion: Cordyceps polysaccharide can increase the capacity of antioxidant in skin fibroblast cells.