Objective: To observe the effect of Guanxinping on myocardial ischemic injury induced by isoprenaline in rats. Method: Rat myocardial ischemia was induced by subcutaneous injection of isoprenaline(30 mg·kg-1). The effect of Guanxinping on the lactate dehydrogenase (LDH)

serum creatine kinase (CK)

malondial dehyde (MDA)and superoxide dismutase (SOD)was observed. The descent of J point at different time after injection of isoprenaline was examined

and pathological investigation of myocardial injury in rats was carried out. Result: Guanxinping could obviously inhibit the activities of serum CK

LDH

and MDA

enhance serum SOD activity(P＜0.01

P＜0.05). Guanxinping could inhibit descent of J point in rat myocardial ischemia induced by isoprenaline(P＜0.05

P＜0.01)

and significantly reduce the extent of myocardial pathological damage. Conclusion: Guanxinping can obviously ameliorate myocardial ischemic injury induced by isoprenaline in rat.