Objective: To investigate the effect of Ge Pi decoction on regulation of monocyte chemoattractant protein-1(MCP-1)level to reverse early diabetic nephropathy(DN). Method: STZ diabetes model were induced by high lipoids and high glucose diet combined with intraperitoneal injection of small dose streptozotocin(STZ)(n=41). STZ-induced diabetes model of Wistar male rats were divided into the control group(n=14)

the Traditional Chinese medicine(Ge Pi Decoction)treatment group(n=13)

and the western medicine(benazepril)treatment group(n=14). After 8 weeks

detection of each group were carried out about weight

kidney weight index

blood glucose

urinary albumin microdosis

urinary albumin

blood and urine MCP-1

8-iso-prostaglandin F2a(8-iso-PGF2α)and tumor necrosis factor-α(TNF-α)

and oservation were performed on the pathological change of the rats renal with light microscope. Result: Compared with those in the control group

the body weight and kidney weight index were decreased in the Ge Pi Decoction treatment(P<0.05). Microdosis urin-albumin

MCP-1

8-iso-PGF2α and TNF were decreased significantly(P<0.01). There was no significant difference between Ge Pi Decoction treatment group and benazepril treatment group(P>0.05).In addition

there were positive correlation between 8-iso-PGF2α

MCP-1

TNF-α and UAER in each group. Ge Pi Decoction can relieve kidney hypertrophy

mesangial matrix hyperplasia and sclerosis. Conclusion: There are autoimmunity inflammation and oxidative stress in diabetic nephropathy.Ge Pi Decoction can inhibit various inflammatory factors in diabetic nephropathy.