Effects of Purpura Granules on Levels of Interleukin-11 and Transforming Growth Factor-beta in Peripheral Blood of Mouse Model with Idiopathic Thrombocytopenic Purpura
QIAO Tie, FAN Ying, LIN Shu-ru, et al. Effects of Purpura Granules on Levels of Interleukin-11 and Transforming Growth Factor-beta in Peripheral Blood of Mouse Model with Idiopathic Thrombocytopenic Purpura[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(8): 117-119.
QIAO Tie, FAN Ying, LIN Shu-ru, et al. Effects of Purpura Granules on Levels of Interleukin-11 and Transforming Growth Factor-beta in Peripheral Blood of Mouse Model with Idiopathic Thrombocytopenic Purpura[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(8): 117-119.DOI:
Objective: To explore the relationship between the changes in interleukin-11(IL-11) and transforming growth factor-beta1(TGF-β1) and occurrence of idiopathic thrombocytopenic purpura(ITP)by investigating content of IL-11 and TGF-β1 in peripheral blood of the mouse model with ITP. Method: Contents of IL-11 and TGF-β1 in peripheral blood of the mouse model with ITP were measured by ELISA. Result: Contents of IL-11 and TGF-β1 in peripheral blood of model group increased significantly
and it was statistically significant(P<0.05). Conclusion: IL-11 and TGF-β1 play an important role in occurrence of ITP
and Purpura Granules can cure ITP effectively by regulating contents of IL-11 and TGF-β1 in peripheral blood.