Objective: To study the influence of Huangqi Guizhi Wuwu Decoction (Hw) on hemorheological indexes in rats with chilblains. Method: Rat chilblains model was established through soaking rats feet in low temperature 40% alcohol solution. The contents of TXB2 and 6-k-PGF1α in plasma of the rats taken by Hw through different ways such as oral administration

the immersion

and the oral administration+soak(IS) were determined. Result: Compared with the normal control group

blood viscosity

blood plasma viscosity

index of RBC aggragation and index of deformation in rats of model group were significantly increased (P<0.05)

TXB2 were significantly increased (P<0.05) and 6-k-PGF1α decreased (P<0.01). Compared with the rats of model group

TXB2 decreased (P<0.05) significantly in plasma of the rats with the Hw taken by the IS; PGF1αincreased (P<0.05 or P<0.01) in plasma of the rats with the Hw taken by the oral administration and the IS. The Hw groups taken by different ways had improved hemorheological indexes to varying degrees. Conclusion: The model of chilblains brings about the unbalance of immunological function

microcycle barrier and a state of forming thrombus easily. The Hw groups taken by different ways can adjust the abnormal changes in immunology

the unbalance of TXA2-PGI2 and improve blood rheology targets

and the group of Hw taken by the IS is better than those of the other two Hw groups.