Objective: To investigate the effect of Shuangshenling Granules on treating chronic renal failure (CRF) and explore its mechanism to provide experimental basis for clinical application. Method: Rat model of CRF was induced by adenine and the effect of Shuangshenling Granules was tested. The effect on hemorheological indexes of blood stasis in rats

such as blood viscosity at low shear rate

was investigated; and the effects on microcirculatory disturbance and immunological function in mice were also tested. Result: Shuangshenling Granules could decrease the increased BUN and Crea induced by adenine in rat. The Granules could also improve the hemorheological indexes

microcirculation and immunological function in the experimental animals. Conclusion: Shuangshenling Granules have the function of delaying the progress of CRF which is related with hemorheological indexes

microcirculation and immunological function.