金铁锁总皂苷镇痛作用及其对佐剂性关节炎大鼠c-fos基因的表达的影响

王学勇; 张元; 许建阳; 邱德文

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金铁锁总皂苷镇痛作用及其对佐剂性关节炎大鼠c-fos基因的表达的影响

更新时间：2024-01-04

- 金铁锁总皂苷镇痛作用及其对佐剂性关节炎大鼠c-fos基因的表达的影响
- The Analgesic Effect of Total Saponins of Psammosilene Tunicoids and its Suppression of c-fos Gene Expression in Adjuvant-induced Arthritis Rats
- 中国实验方剂学杂志 2010年16卷第3期页码：94-96
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- 纸质出版日期：2010
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王学勇, 张元, 许建阳, 等. 金铁锁总皂苷镇痛作用及其对佐剂性关节炎大鼠c-fos基因的表达的影响[J]. 中国实验方剂学杂志, 2010,16(3):94-96.

WANG Xue-yong, ZHANG Yuan, XU Jian-yang, et al. The Analgesic Effect of Total Saponins of Psammosilene Tunicoids and its Suppression of c-fos Gene Expression in Adjuvant-induced Arthritis Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(3): 94-96.
王学勇, 张元, 许建阳, 等. 金铁锁总皂苷镇痛作用及其对佐剂性关节炎大鼠c-fos基因的表达的影响[J]. 中国实验方剂学杂志, 2010,16(3):94-96. DOI：

WANG Xue-yong, ZHANG Yuan, XU Jian-yang, et al. The Analgesic Effect of Total Saponins of Psammosilene Tunicoids and its Suppression of c-fos Gene Expression in Adjuvant-induced Arthritis Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(3): 94-96. DOI：

摘要

目的 :探讨金铁锁总皂苷(TSPT)镇痛作用及其机制

进一步揭示金铁锁总皂苷抗类风湿关节炎的药理作用基础。方法 :采用热板法初步评价TSPT的镇痛效果

建立大鼠佐剂性关节炎(AA)模型

运用免疫组化研究TSPT对c-fos基因表达产物FOS蛋白水平的影响。结果 :TSPT具有明显的镇痛作用

大剂量组优于中药阳性对照组;TSPT还能明显抑制AA大鼠炎性疼痛中枢及外周组织中c-fos基因的表达。结论 :TSPT具有良好的镇痛效果

其镇痛作用可能与抑制中枢和外周神经c-fos基因的表达有关

为深入研究其抗类风湿关节炎作用奠定了基础。

Abstract

Objective: To investigate the analgesic effect and possible mechanism of total saponins of Psammosilene tunicoids (TSPT) for further reveal the mechanism of its antiarthritic effects. Methods: The method of hot plate was used to value the primary analgesic effect of TSPT and the c-fos gene expression was investigated by immunohistochemical method in tissues from adjuvant-induced arthritis(AA) rats. Results : TSPT showed obvious analgesic effects and when administration dose reaching 10 mg/kg

this effect approached alidine and surpassed the positive control of Fengshinin injection. Further more

TSPT could obviously suppress the c-fos gene expression both in center and periphery tissues in adjuvant-induced arthritis rats. Conclusion: TSPT has good analgesic effects and this effect might closely relate to c-fos gene expression both in center and periphery tissues in AA rats. This study would help to further investigate the possible mechanism of anti-rheumatoid arthritis for TSPT.

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