微透析法进行盐酸青藤碱肌注给药的药代动力学研究

张英丰; 王利胜; 周莉玲

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微透析法进行盐酸青藤碱肌注给药的药代动力学研究

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- 微透析法进行盐酸青藤碱肌注给药的药代动力学研究
- Pharmacokinetics Study on Sinomenine Hydrochloride in Rats with Administration route of Intramscular Injection by Using Microdialysis Method
- 中国实验方剂学杂志 2010年16卷第8期页码：109-112
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- 基金信息：
  
  国家自然科学基金资助项目(30672669,30873443);中国博士后基金资助项目(20070420509)
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- 纸质出版日期：2010
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张英丰, 王利胜, 周莉玲. 微透析法进行盐酸青藤碱肌注给药的药代动力学研究[J]. 中国实验方剂学杂志, 2010,16(8):109-112.

ZHANG Ying-feng, WANG Li-sheng, ZHOU Li-ling. Pharmacokinetics Study on Sinomenine Hydrochloride in Rats with Administration route of Intramscular Injection by Using Microdialysis Method[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(8): 109-112.
张英丰, 王利胜, 周莉玲. 微透析法进行盐酸青藤碱肌注给药的药代动力学研究[J]. 中国实验方剂学杂志, 2010,16(8):109-112. DOI：

ZHANG Ying-feng, WANG Li-sheng, ZHOU Li-ling. Pharmacokinetics Study on Sinomenine Hydrochloride in Rats with Administration route of Intramscular Injection by Using Microdialysis Method[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(8): 109-112. DOI：

摘要

目的 :微透析法进行盐酸青藤碱肌注给药的药代动力学研究。方法 :微透析探针植入大鼠的右心室

实时、活体采集肌注盐酸青藤碱后的透析液样品

HPLC检测样品浓度

微透析样品浓度经校正后进行房室和非房室模型拟合。结果 :盐酸青藤碱肌注后Cmax为3.127 mg·L-1

Tmax为101 min

MRT为191 min

结果表盐酸青藤碱肌注后血药浓度呈一级速率、一室模型。结论 :微透析法能较好的反映盐酸青藤碱肌注给药的药动学特征

微透析采样手段可作为药动学研究的理想手段。

Abstract

Objective: To explore the pharmacokinetics of sinomenine hydrochloride by using microdialysis method. Method: The microdialysis probe was introduced to right ventricle of rats as sampling tools for real-time and in vivo collecting samples after intramscular injection. The dialysate samples were determined by HPLC. After the dialysate concentration was calibrated

the blood-drug concentration was fitted with compartment and noncompartment model. Result: The results shows that physiological disposition of Sinomenine Hydrochloride was fitted to first order rate and open one-compartment model. The main pharmcokinetics parameters were as following: Cmax 3.127 mg·L-1

Tmax 101 min

MRT 191 min. Conclusion: The pharmacokinetics characteristics of Sinomenine Hydrochloride was collected by using microdialysis method which could been selected as study tool.

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