Objective: To investigate the pharmacological action of ginger (Zingiber officinale Roscoe) oleoresin on central nervous system (CNS). Method: : After i.g. administration of ginger oleoresin upon mice

the spontaneous activity of mice was determined

latency and sleeping time induced by pentobarbitol were measured

strychinine-induced convulsion was observed

acetic acid-induced writhing and hot plate-induced pain were tested. Results: Ginger oleoresin could significantly reduced mice locomotor activity

prolonged pentobarbital-induced sleep time of mice

delayed latency of convulsion induced by strychnine

reduced the number of writhing and stretching induced by the acetic acid and delayed latency of reaction to the thermal stimulus. Conclusion: Ginger oleoresin has significant inhibitory effect on CNS.