Objective: To investigate therapeutic effects of Wuzi Yanzong recipe by different doses on male animal model with sexual dysfunction. Method: Seventy male rats were used and classified to be 7 groups. Sixty male rats were castrated to be an animal model of sexual dysfunction. Wuzi Yanzong recipe was administrated daily oral by for consecutive 4 weeks. After cessation of the treatment

the latent period of penis erection in each rat was measured and then the rats were sacrificed and dissected. The spleen

thymus and male sex organs were weighed for calculating index. The blood samples were taken for measurement of serum testosterone (T)

luteal hormone (LH)

follicle stimulating hormone (FSH)

nitrogen monoxide (NO)

superoxide dismutase(SOD)

and maleic dialdehyde(MDA). Results: The latent period of penis erection in each Wuzi Yanzong treatment group was significantly shortened. Serum T in large dose group

NO and SOD were increased while MDA was decreased in large and middle dose group significantly when compared to the animal model control group.Besides

index of levator ani muscle

seminal vehicle and prostate were significantly increased in Wuzi Yanzong each treatment group

the index of preputial glands was increased with large dose of the treatment

respectively. Conclusion : Wuzi Yanzong recipe may have therapeutic effects to improve asthenia of renal Yang and penis erection dysfunction.