Objective: To evaluate the effectiveness of ShuYu Capsule in patients with vascular depresion (VD). Method: The investigational drugs were packed by blind method. A randomized

double-blind and controlled trial was conducted on sixty patients with VD. The sixty patients were randomly divided into treatment group (n=30)

orally ShuYu Capsule 3# tid and Fluoxetine capsule placebo 20mg qd

for 8 wk.and control group (n=30)

orally Fluoxetine capsule 20mg qd

and ShuYu Capsule placebo 3# tid

for 8 wk. All subjects were assessed by HAMD

MMSE

CGI

NDS and Blood lipids. Result: ShuYu Capsule can be reduced the scores of HAMD

MMSE

CGI of Before and after treatment

The difference has statistics meaning (P<0.05) between two groups; Can reduce the NDS grading and blood LDL-C level (P<0.05) after 8 w in treatment group

But NDS grade and the blood LDL-C level can not be improved obviously (P>0.05) in control group. Have not statistics significantly (P>0.05) in the always efficient comparative difference between two groups of treatment. Conclusion: ShuYu Capsule has better clinical effect in vascular depresion

equal effect to Fluoxetine capsule.