Objective: To research the effect of Lianqi Xiaoke Capsule on type 2 diabetic rats. Method : Type 2 diabetic rat model wase induced with high sucrose-fat diet for 4 weeks and streptozotocin ip for 30 mg ·kg-1

all animals were grouped and administrated with drugs for 8 weeks. The fasting blood glucose

insulin

insulin sensitivity index

total cholesterol

triglyceride

superoxide dismutase and malondialdehyde were assessed and pancreatic pathological changes were observed. Result : ① model group vs normal control group: the fasting blood glucose

total cholesterol

triglyceride

malondialdehyde were obviously increased(P<0.05

P<0.01)

otherwise insulin

insulin sensitivity index

superoxide dismutase decreased (P<0.05)

pancreatic damage were appeared; ② Lianqi Xiaoke Capsule treatment groups vs. model group: the fasting blood glucose

total cholesterol

triglyceride

malondialdehyde were significantly decreased (P<0.05

P<0.01)

and insulin

insulin sensitivity index

superoxide dismutase increased (P<0.05)

pancreatic damage were ameliorated. Conclusion : Lianqi Xiaoke Capsule could decrease fasting blood glucose and blood lipids via ameliorating pancreatic damage and insulin resistance

and inhibition of oxidative stress.